Editorial: Unfortunate, but Timely

An Unfortunate Blow

Editorial: "Approved but not funded".

A common letter from the National Institutes of Health reads something like this: "We are pleased to inform you that your request for research funds has been approved by the NIH review committee and by the Council." (Up go your spirits.) "Unfortunately," it continues, "there seems little likelihood that there will be adequate money available to fund the project." (Down go your hopes.) Because o...

A Timeless but Timely Connection between Replication and Recombination

Initiation of meiotic recombination by DNA double-strand break formation is temporally coordinated with replication. Murakami and Keeney show that this coordination requires recruitment of the Dbf4-dependent kinase to the replication fork by the conserved TIM-TIPIN complex. The same mechanism may regulate other important replication-associated processes.

PLIVA v. Mensing: generic consumers' unfortunate hand.

INTRODUCTION ................................................................................................ 210 I. DRUG APPROVAL PROCESS .......................................................................... 213 A. BRAND-NAME DRUG APPROVAL AND LABELING PROCESS ..................... 213 1. PRE-APPROVAL ...................................................................................... 2...

[Asthma and smoking: an unfortunate combination].

Asthma is an inflammatory disease of the airways in which a key role is played by certain cells and mediators (T-helper 2 cells, mast cells, eosinophils, interleukin 4 and 5). In certain disorders such as irritant-induced asthma, reactive airways dysfunction syndrome, and asthma due to toluene diisocyanate, inflammation is mediated predominantly by T-helper 1 cells, macrophages and neutrophils....